The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma 2 gene is associated with plasma levels of soluble RAGE (Receptor for Advanced Glycation Endproducts) and the presence of peripheral arterial disease

Catalano M., Cortelazzo A., Santi R., Contino L., Demicheli M., YILMAZ Y., ...More

CLINICAL BIOCHEMISTRY, vol.41, no.12, pp.981-985, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 12
  • Publication Date: 2008
  • Doi Number: 10.1016/j.clinbiochem.2008.05.007
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.981-985
  • Bursa Uludag University Affiliated: No

Abstract

Objectives: Recent evidences suggest that the activation of peroxisome proliferator-activated receptor (PPAR)-gamma 2, which plays an important role in vascular homeostasis, also regulates the expression of the Receptor for Advanced Glycation End products (RAGE). In turn, low levels of soluble RAGE (sRAGE) have recently emerged as a valuable biomarker of vascular inflammation. The potential alterations in sRAGE concentrations in peripheral arterial disease (PAD), however, have not been yet investigated. The aim of the present study was to clarify whether the Pro12Ala polymorphism of the PPAR-gamma 2 gene is related to plasma sRAGE levels and the presence of PAD in nondiabetic Italian individuals.