Streptozotocin induced type 1 diabetes mellitus on haematology and erythrocyte sodium potassium in mice

Yalcin M., Altunbas K.

INDIAN VETERINARY JOURNAL, cilt.84, sa.4, ss.365-367, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 84 Sayı: 4
  • Basım Tarihi: 2007
  • Dergi Adı: INDIAN VETERINARY JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.365-367
  • Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

Streptozotocin (STZ) is a pancreatic beta-cell toxin that induces rapid and irreversible necrosis of beta-cell (Junod et al., 1967) and is widely used in making experimental animal models of Insulin dependent diabetes mellitus (IDDM) (Rakieten et al., 1963; Brodsky and Logothetopoules, 1969; Junod et al., 1969; Repur, 1970). It is reported that the i.v. injection of 25-200 mg/kg STZ to rats was able to produce a dose-dependent hyperglycemia (Junod et al., 1967).