Streptozotocin induced type 1 diabetes mellitus on haematology and erythrocyte sodium potassium in mice


Yalcin M., Altunbas K.

INDIAN VETERINARY JOURNAL, vol.84, no.4, pp.365-367, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 84 Issue: 4
  • Publication Date: 2007
  • Journal Name: INDIAN VETERINARY JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.365-367
  • Bursa Uludag University Affiliated: No

Abstract

Streptozotocin (STZ) is a pancreatic beta-cell toxin that induces rapid and irreversible necrosis of beta-cell (Junod et al., 1967) and is widely used in making experimental animal models of Insulin dependent diabetes mellitus (IDDM) (Rakieten et al., 1963; Brodsky and Logothetopoules, 1969; Junod et al., 1969; Repur, 1970). It is reported that the i.v. injection of 25-200 mg/kg STZ to rats was able to produce a dose-dependent hyperglycemia (Junod et al., 1967).