A New Protocol for Collagen-Induced Local Arthritis Model in Balb/c Mice

Guvenc G., Karacay M., AKKOÇ A., Ciftci K., ORAL H. B., YALÇIN M.

TURKISH JOURNAL OF IMMUNOLOGY, cilt.6, sa.1, ss.30-36, 2018 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.25002/tji.2018.771
  • Dergi Adı: TURKISH JOURNAL OF IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.30-36
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Introduction: Numerous models have been described to study the pathogenesis of rheumatoid arthritis, and to develop new therapies; but each of these models has their own limitations. Nowadays, the collagen-induced arthritis (CIA) mouse model is the most commonly used model for rheumatoid arthritis studies in certain mouse strain like DBA/1 mouse. This study aimed to describe a new protocol for local induction of arthritis in Balb/c mice, including the monitoring of clinical arthritis and the protocols for histological examination of paws of mice.