A New Protocol for Collagen-Induced Local Arthritis Model in Balb/c Mice

Guvenc G., Karacay M., AKKOÇ A., Ciftci K., ORAL H. B., YALÇIN M.

TURKISH JOURNAL OF IMMUNOLOGY, vol.6, no.1, pp.30-36, 2018 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.25002/tji.2018.771
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.30-36
  • Bursa Uludag University Affiliated: Yes


Introduction: Numerous models have been described to study the pathogenesis of rheumatoid arthritis, and to develop new therapies; but each of these models has their own limitations. Nowadays, the collagen-induced arthritis (CIA) mouse model is the most commonly used model for rheumatoid arthritis studies in certain mouse strain like DBA/1 mouse. This study aimed to describe a new protocol for local induction of arthritis in Balb/c mice, including the monitoring of clinical arthritis and the protocols for histological examination of paws of mice.