A New Protocol for Collagen-Induced Local Arthritis Model in Balb/c Mice
TURKISH JOURNAL OF IMMUNOLOGY, cilt.6, sa.1, ss.30-36, 2018 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6 Sayı: 1
- Basım Tarihi: 2018
- Doi Numarası: 10.25002/tji.2018.771
- Dergi Adı: TURKISH JOURNAL OF IMMUNOLOGY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.30-36
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Introduction: Numerous models have been described to study the pathogenesis of rheumatoid arthritis, and to develop new therapies; but each of these models has their own limitations. Nowadays, the collagen-induced arthritis (CIA) mouse model is the most commonly used model for rheumatoid arthritis studies in certain mouse strain like DBA/1 mouse. This study aimed to describe a new protocol for local induction of arthritis in Balb/c mice, including the monitoring of clinical arthritis and the protocols for histological examination of paws of mice.