Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions

ERYILMAZ, IŞIL; ÇEÇENER, GÜLŞAH; Erer, Sevda; EGELİ, ÜNAL; TUNCA, BERRİN; ZARİFOĞLU, MEHMET; ELİBOL, BÜLENT; Tokcaer, Ayse; Saka, Esen; Demirkiran, Meltem; Akbostanci, Cenk; DOĞU, OKAN; Colakoglu, Beril; Kenangil, Gulay; Kaleagasi, Hakan

doi:10.1080/01616412.2017.1368141

Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions

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ERYILMAZ I. E., ÇEÇENER G., Erer S., EGELİ Ü., TUNCA B., ZARİFOĞLU M., ...More

NEUROLOGICAL RESEARCH, vol.39, no.11, pp.965-972, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 39 Issue: 11
Publication Date: 2017
Doi Number: 10.1080/01616412.2017.1368141
Journal Name: NEUROLOGICAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.965-972
Keywords: Early-onset Parkinson's disease, epigenetic, methylation, SNCA, PARK2, ALPHA-SYNUCLEIN, LEUKOCYTE DNA, GENE, MUTATIONS, EXPRESSION
Bursa Uludag University Affiliated: Yes

Abstract

Background and aim: The effect of epigenetic modifications in the genes related to Parkinson's disease (PD) is still unclear. In the present study, we investigated methylation status of SNCA and PARK2 genes in patients with early-onset Parkinson's disease (EOPD).