Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions

Eryılmaz, IŞIL; Çeçener, GÜLŞAH; Erer, ÇİĞDEM; Egeli, ÜNAL; Tunca, BERRİN; Zarifoğlu, MEHMET; Elibol, Bülent; Tokcaer, Ayse; Saka, Esen; Demirkiran, Meltem; Akbostanci, Cenk; Doğu, Okan; Colakoglu, Beril; Kenangil, Gulay; Kaleagasi, Hakan

doi:10.1080/01616412.2017.1368141

Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions

Atıf İçin Kopyala

Eryılmaz I. E., Çeçener G., Erer S., Egeli Ü., Tunca B., Zarifoğlu M., ...Daha Fazla

NEUROLOGICAL RESEARCH, cilt.39, sa.11, ss.965-972, 2017 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 39 Sayı: 11
Basım Tarihi: 2017
Doi Numarası: 10.1080/01616412.2017.1368141
Dergi Adı: NEUROLOGICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.965-972
Anahtar Kelimeler: Early-onset Parkinson's disease, epigenetic, methylation, SNCA, PARK2, ALPHA-SYNUCLEIN, LEUKOCYTE DNA, GENE, MUTATIONS, EXPRESSION
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background and aim: The effect of epigenetic modifications in the genes related to Parkinson's disease (PD) is still unclear. In the present study, we investigated methylation status of SNCA and PARK2 genes in patients with early-onset Parkinson's disease (EOPD).