Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions


ERYILMAZ I. E. , ÇEÇENER G., Erer S., EGELİ Ü., TUNCA B., ZARİFOĞLU M., ...More

NEUROLOGICAL RESEARCH, vol.39, no.11, pp.965-972, 2017 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 11
  • Publication Date: 2017
  • Doi Number: 10.1080/01616412.2017.1368141
  • Journal Name: NEUROLOGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.965-972
  • Keywords: Early-onset Parkinson's disease, epigenetic, methylation, SNCA, PARK2, ALPHA-SYNUCLEIN, LEUKOCYTE DNA, GENE, MUTATIONS, EXPRESSION

Abstract

Background and aim: The effect of epigenetic modifications in the genes related to Parkinson's disease (PD) is still unclear. In the present study, we investigated methylation status of SNCA and PARK2 genes in patients with early-onset Parkinson's disease (EOPD).