Association of adiponectin receptor (Adipo-R1/-R2) expression and colorectal cancer.


AYYILDIZ T., Dolar E., UĞRAŞ N., BALABAN ADIM Ş., YERCİ Ö.

Asian Pacific journal of cancer prevention : APJCP, vol.15, no.21, pp.9385-90, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 21
  • Publication Date: 2014
  • Doi Number: 10.7314/apjcp.2014.15.21.9385
  • Journal Name: Asian Pacific journal of cancer prevention : APJCP
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.9385-90
  • Keywords: Adiponectin receptor, Adipo-R1/-R2, colorectal carcinoma, prognosis, PLASMA ADIPONECTIN, COLON-CANCER, SERUM ADIPONECTIN, INSULIN SENSITIVITY, TISSUE EXPRESSION, GASTRIC-CANCER, RISK, PROTEIN, OBESITY, HYPOADIPONECTINEMIA
  • Bursa Uludag University Affiliated: Yes

Abstract

Introduction: Human adiponectin (ApN) is a 30 kDa glycoprotein of 244-amino acids which is extensively produced by adipocytes. ApN acts via two receptors, namely adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Studies have shown the presence of Adipo-R1 and Adipo-R2 expression immunohistochemically in human colorectal cancers (CRCs). However, only a few studies exist which investigated effects of adiponectin receptor expression on CRC characteristics. Objectives: In the present study, we aimed to explore Adipo-R1/-R2 expression in human colorectal cancers and any association with clinicopathological characteristics and survival. Materials and Methods: The study enrolled 58 colorectal cancer patients with tumor resection and a control group of 30 subjects with normal colon mucosa. Results: Positivity for Adipo-R1/-R2 expression was significantly more common in the control group in comparison to the patient group (both p<0.001). There was no significant association between Adipo-R1/-R2 expression and clinicopathological characteristics including age, sex tumor location, pTNM stage, Duke's stage, metastasis, histological differentiation, perineural invasion, venous invasion sex, lymphatic invasion, cancer-related mortality, tumor size and recurrence. AdipoR1/-R2 positivity was also not significantly linked to progression-free or overall survival [p values (0.871, 0.758) and (0.274, 0.232), respectively]. Conclusions: Although significantly reduced Adipo-R1/-R2 expression was found in colorectal cancer patients, it had no influence on survival.