Maternal serum autotaxin levels in early- and late-onset preeclampsia

Erenel H., Yilmaz N., Cift T., Bulut B., Sozen I., Cetin B. A., ...Daha Fazla

HYPERTENSION IN PREGNANCY, cilt.36, sa.4, ss.310-314, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/10641955.2017.1388389
  • Dergi Adı: HYPERTENSION IN PREGNANCY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.310-314
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Purpose: We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregnant patients at a university hospital.Methods: A total of 55 singleton preeclamptic women who delivered at Cerrahpasa Medical Faculty were included in the study. The patients were subdivided into two groups: early-onset preeclampsia (n=31) and late-onset preeclampsia (n=24). Demographic and clinical data were compared between early-onset and late-onset preeclamptic patients. The control group was composed of 32 healthy pregnant patients.Results: The mean autotaxin levels were 1.160.97 and 0.7 +/- 0.35ng/ml in the early- and late-onset preeclampsia groups, respectively. Autotaxin levels were significantly higher in early-onset preeclampsia group compared with late-onset preeclampsia group. Autotaxin levels were found to be significantly higher in preeclamptic patients compared with control group. Serum autotaxin levels showed a significant positive correlation with maternal systolic, diastolic blood pressures and uric acid levels.Conclusion: Autotaxin might be a promising marker for detecting early-onset preeclampsia. However, further studies are necessary to confirm this hypothesis.