Olea europaea leaf extract alters microRNA expression in human glioblastoma cells

TUNCA B., Tezcan G., ÇEÇENER G., EGELİ Ü., Ak S., MALYER H., ...More

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.138, no.11, pp.1831-1844, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 138 Issue: 11
  • Publication Date: 2012
  • Doi Number: 10.1007/s00432-012-1261-8
  • Journal Name: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1831-1844
  • Keywords: Olea europaea leaf extract, Temozolomide, Glioblastoma multiforme, MicroRNA, ADENOCARCINOMA CELLS, INITIATING CELLS, HUMAN CANCER, STEM-CELLS, OLIVE, SOX2, DIFFERENTIATION, IDENTIFICATION, OLEUROPEIN, TUMORIGENICITY
  • Bursa Uludag University Affiliated: Yes

Abstract

Glioblastoma multiforme (GBM) is the most common and the most lethal form of primary malignant tumors in the central nervous system. There is an increasing need for the development of more efficient therapeutic approaches for the treatment of these patients. One of the most attractive cancer therapy methods to date is the induction of tumor cell death by certain phytochemicals. Interestingly, bioactive compounds have been shown to alter micro RNA (miRNA) expression involved in several biological processes at the posttranscriptional level. The present study aimed to evaluate whether Olea europaea leaf extract (OLE) has an anticancer effect and modulates miRNA expression in GBM.