Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study

Yilmaz, Alev; Afonso, Alberto; AKİL, İPEK; Aksu, Bagdagul; ALPAY, HARİKA; Atmis, Bahriye; AYDOĞ, ÖZLEM; Bayram, Meral; Bilge, Ilmay; KAPLAN BULUT, İPEK; BÜYÜKKARAGÖZ, BAHAR; ÇOMAK, ELİF; Demir, Belde; Dincel, Nida; DÖNMEZ, OSMAN; Durmus, Mehmet; Dursun, Hasan; DÜŞÜNSEL, Ruhan; DÜZOVA, ALİ; ERTAN, PELİN; Gedikbasi, Asuman; Goknar, Nilufer; Guven, Sercin; Hacihamdioglu, Duygu; Jankauskiene, Augustina; KALYONCU, MUKADDES; KAVUKÇU, SALİH; UZUN KENAN, BAHRİYE; Kucuk, Nuran; Kural, Bahar; Montini, Giovanni; Morello, William; Nayir, Ahmet; Obrycki, Lukasz; Omer, Beyhan; Ozdemir, Ebru; Ozkayin, Nese; Paripovic, Dusan; Pehlivanoglu, Cemile; Saygili, Seha; Schaefer, Susanne; SÖNMEZ, FERAH; TABEL, YILMAZ; TAŞ, NESRİN; Tasdemir, Mehmet; Teixeira, Ana; Tekcan, Demet; Tulpar, Sebahat; Turkkan, Ozde; Uysal, Berfin; Uysalol, Metin; Vaiciuniene, Daiva; Yavuz, Sevgi; YEL, SİBEL; Yildirim, Tarik; Yildirim, Zeynep; YILDIZ, NURDAN; YÜKSEL, SELÇUK; Yurtseven, Eray; Schaefer, Franz; TOPALOĞLU, REZAN; KARABAY BAYAZIT, AYSUN; Litwin, Mieczyslaw

doi:10.1007/s00467-022-05664-5

Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study

Yilmaz A., Afonso A. C. , AKİL İ., Aksu B., ALPAY H., Atmis B., ...More

PEDIATRIC NEPHROLOGY, 2022 (Journal Indexed in SCI)

Publication Type: Article / Article
Publication Date: 2022
Doi Number: 10.1007/s00467-022-05664-5
Title of Journal : PEDIATRIC NEPHROLOGY
Keywords: Children, Urinary tract infection, UTI, Heat shock proteins, HSP70, HEAT-SHOCK PROTEINS, FLUID

Abstract

Background The accuracy of conventional urinalysis in diagnosing urinary tract infection (UTI) in children is limited, leading to unnecessary antibiotic exposure in a large fraction of patients. Urinary heat shock protein 70 (uHSP70) is a novel marker of acute urinary tract inflammation. We explored the added value of uHSP70 in discriminating UTI from other infections and conditions confused with UTI.