Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients


COŞKUN N. F. , Yilmaz D., URSAVAŞ A., Uzaslan E., Ege E.

MULTIDISCIPLINARY RESPIRATORY MEDICINE, vol.5, no.3, pp.168-172, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1186/2049-6958-5-3-168
  • Journal Name: MULTIDISCIPLINARY RESPIRATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.168-172
  • Keywords: D-dimer, massive pulmonary embolism, pulmonary embolism, DEEP-VEIN THROMBOSIS, VENOUS THROMBOEMBOLISM, EXCLUSION, DIAGNOSIS, MORTALITY, FIBRIN, ASSAY, MODEL
  • Bursa Uludag University Affiliated: Yes

Abstract

Pulmonary embolism (PE) is diagnosed with increasing frequency nowadays due to advances in the diagnostic methods and the increased awareness of the disease. There is a tendency to use non invasive diagnostic methods for all diseases. D-dimer is a fibrin degradation product. We aimed to detect the relationship between disease severity and the D-dimer levels measured with two different methods. We compared D-dimer levels in cases of massive vs. non-massive PE. A total of 89 patients who were diagnosed between 2006 and 2008 were included in the study. Group 1 included patients whose D-dimer levels were measured with the immunoturbidimetric polyclonal antibody method (D-dimerPLUS (R)), while Group 2 patients made use of the immunoturbidimetric monoclonal antibody method (InnovanceD-DIMER (R)). In each group, the D-dimer levels of those with massive and non-massive PE were compared, using the Mann Whitney U test. The mean age of Group 1 (25F/26M) was 56.0 +/- 17.9 years, and that of Group 2 (22F/16M) was 52.9 +/- 17.9 years. There was no statistical difference in gender and mean age between the two groups (p > 0.05). In Group 1, the mean D-dimer level of massive cases (n = 7) was 1444.9 +/- 657.9 mu g/L and that of non-massive PE (n = 34) was 1304.7 +/- 350.5 mu g/L (p > 0.05). In Group 2, the mean D-dimer level of massive cases (n = 6) was 9.7 +/- 2.2 mg/L and that of non-massive PE (n = 32) was 5.9 +/- 1.3 mg/L (p < 0.05). The mean D-dimer levels of massive cases as measured with the immunoturbidimetric monoclonal antibody method were significantly higher. Pulmonary embolism patients whose D-dimer levels are higher (especially higher than 6.6 mg/L) should be considered as possibly having massive embolism. Diagnostic procedures and management can be planned according to this finding.