Effects of Nicotine Metabolites on Nicotine Withdrawal Behaviors in Mice

Elhassan S., Bagdas D., Damaj M. I.

NICOTINE & TOBACCO RESEARCH, vol.19, no.6, pp.763-766, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1093/ntr/ntx045
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.763-766
  • Bursa Uludag University Affiliated: No


Introduction: Rodent studies suggest that nicotine metabolites and minor tobacco alkaloids such as nornicotine and cotinine may promote cigarette smoking by enhancing nicotine rewarding and reinforcing effects. However, there is little information on the effects of these minor tobacco alkaloids on nicotine withdrawal. The present studies were conducted to determine whether the minor tobacco alkaloids nornicotine and cotinine exhibit nicotine-like behavioral effects in a mouse model of spontaneous nicotine withdrawal.