Serum levels of endocan, claudin-5 and cytokines in migraine

Yucel M., Kotan D., Ciftci G. G., Ciftci I. H., Cikriklar H. İ.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.20, no.5, pp.930-936, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 5
  • Publication Date: 2016
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.930-936
  • Keywords: Migraine, Endocan, Claudin-5, Inflammation, Cytokine, ESM-1, AMERICAN MIGRAINE, MARKER
  • Bursa Uludag University Affiliated: No

Abstract

OBJECTIVE: Endothelial dysfunction is involved in inflammatory disorders, migration, angiogenesis, and tumor progression. There is a known relationship between migraine and inflammation; however, there are conflicting data as to whether there is a link between migraine and endothelial dysfunction. The current study aimed to determine the relationships between migraine and levels of serum Endocan (ESM-1), Claudin-5 (CLDN5), IL-1 beta, IL-6 and TNF-alpha levels, which are proven indicators of endothelial dysfunction and inflammation in patients with migraine.