Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency.

Kıykım, Ayça; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Çekiç, ŞÜKRÜ; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Kilic, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Agrebi, Nourhen; Kara, Manolya; Özen, Ahmet; Somer, SARA; Özen, Ahmet; Aktay Ayaz, Nuray; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Kilic Ss, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Özen, Ahmet; Barış, Safa

doi:10.1016/j.jaip.2019.06.011

Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency.

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Kıykım A., Özen A. O., Özen A. O., Özen A. O., Özen A. O., Çekiç Ş., ...More

The journal of allergy and clinical immunology. In practice, vol.7, no.8, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 7 Issue: 8
Publication Date: 2019
Doi Number: 10.1016/j.jaip.2019.06.011
Journal Name: The journal of allergy and clinical immunology. In practice
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: LPS-responsive beige-like anchor, Immune dysregulation, Abatacept, T follicular helper cells, Autoimmunity, IMMUNE DYSREGULATION, CTLA-4 CHECKPOINT, MUTATIONS, POLYENDOCRINOPATHY, ENTEROPATHY, DISEASE
Bursa Uludag University Affiliated: Yes

Abstract

BACKGROUND: LPS-responsive beige-like anchor (LRBA) deficiency presents with susceptibility to infections, autoimmunity, and lymphoproliferation. The long-term efficacy of cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin (abatacept) as targeted therapy for its immune dysregulatory features remains to be established.