Autoantibodies against type I IFNs in patients with critical influenza pneumonia.

Zhang Q., Pizzorno A., Miorin L., Bastard P., Gervais A., Le Voyer T., ...Daha Fazla

The Journal of experimental medicine, cilt.219, sa.11, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 219 Sayı: 11
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1084/jem.20220514
  • Dergi Adı: The Journal of experimental medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

In an international cohort of 279 patients with hypoxemic influenza pneumonia, we identified 13 patients (4.6%) with autoantibodies neutralizing IFN-alpha and/or -omega, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine.