Autoantibodies against type I IFNs in patients with critical influenza pneumonia.

Zhang Q., Pizzorno A., Miorin L., Bastard P., Gervais A., Le Voyer T., ...More

The Journal of experimental medicine, vol.219, no.11, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 219 Issue: 11
  • Publication Date: 2022
  • Doi Number: 10.1084/jem.20220514
  • Journal Name: The Journal of experimental medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Bursa Uludag University Affiliated: Yes


In an international cohort of 279 patients with hypoxemic influenza pneumonia, we identified 13 patients (4.6%) with autoantibodies neutralizing IFN-alpha and/or -omega, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine.