A comparative study on the genotoxic effect of pyrimethamine in bone marrow and spermatogonial mice cells

Celikler, SERAP; Aydemir, NİLÜFER; Bilaloglu, Rahmi

doi:10.1515/znc-2007-9-1009

A comparative study on the genotoxic effect of pyrimethamine in bone marrow and spermatogonial mice cells

Atıf İçin Kopyala

Celikler S., Aydemir N., Bilaloglu R.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, cilt.62, ss.679-683, 2007 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 62
Basım Tarihi: 2007
Doi Numarası: 10.1515/znc-2007-9-1009
Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.679-683
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Pyrimethamine is an antimalarial agent widely used in clinical therapy. We aimed to compare its mutagenic potential in mammalian spermatogonial and bone marrow cells. For studying chromosomal aberrations mice were treated acutely (single treatment) with 4 dose levels of pyrimethamine (5, 10, 20 and 40 mg/kg). Pyrimethamine was found to produce a significant increase in structural chromosomal aberrations after acute treatment in bone marrow cells of mice (p < 0.001). It also induced chromosome abnormalities in spermatogonial cells (p < 0.05) at the highest dose.