Contribution of functional dopamine D2 and D3 receptor variants to motor and non-motor symptoms of early onset Parkinson's disease

Eryılmaz I. E., Erer S., Zarifoğlu M., Egeli Ü., Karakus E., Yurdacan B., ...Daha Fazla

Clinical Neurology and Neurosurgery, cilt.199, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 199
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.clineuro.2020.106257
  • Dergi Adı: Clinical Neurology and Neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, EMBASE, MEDLINE
  • Anahtar Kelimeler: Dopamine receptor variants, Parkinson's disease, Pain, Polymorphism
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

© 2020 Elsevier B.V.In the present study, we focused on investigating the contribution of functional dopamine D2 and D3 receptor variants to motor and/or non-motor symptoms of early onset Parkinson's disease (EOPD). Three functional single nucleotide polymorphisms (SNPs), DRD3 rs6280, DRD2 rs2283265 and DRD2 rs1076560, were genotyped in 128 Turkish EOPD patients and then, statistical analysis was conducted for the potential impacts of SNPs on clinical parameters. All three SNPs were found to be statistically significant in terms of PD-related pain: DRD3 [rs6280; risk allele “T” for pain; p = 0.031; odds ratio (OR)=4.25], DRD2 [rs2283265; risk allele “A” for pain; p = 0.001; OR=8.47] and, DRD2 [rs1076560; risk allele “A” for pain; p = 0.022; OR=4.58]. Additionally, bilateral disease [p = 0.011; OR=5.10] and gender [risk group “female”; p = 0.003; OR=8.53] were also identified as significant univariate risk factors for PD-related pain. Based on logistic regression analysis conducted with the significant univariate risk factors, this the first report to clarify that a female patient with bilateral PD and DRD2 rs2283265 polymorphism has a significant risk for PD-related pain. Our findings might contribute to improve life quality by offering treatment options for pain in PD patients with these clinical and genetic features.