Evaluation of Complete Blood Count Parameters and Hematological Inflammatory Indices at Diagnosis in Childhood Nephrotic Syndrome Çocukluk Çağı Nefrotik Sendromunda Tanı Anındaki Tam Kan Sayımı Parametreleri ve Hematolojik Enflamatuvar İndekslerin Değerlendirilmesi
Guncel Pediatri, vol.24, no.2, pp.136-144, 2026 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 24 Issue: 2
- Publication Date: 2026
- Doi Number: 10.4274/jcp.2026.80008
- Journal Name: Guncel Pediatri
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Page Numbers: pp.136-144
- Keywords: child, complete blood count, mean platelet volüme, Nefrotik sendrom, Nephrotic syndrome, ortalama trombosit hacmi, plateletto-lymphocyte ratio, sistemik immün-enflamasyon indeksi, systemic immuneinflammation index, tam kan sayımı, trombositlenfosit oranı, çocuk
- Open Archive Collection: AVESIS Open Access Collection
- Bursa Uludag University Affiliated: Yes
Abstract
Introduction: Nephrotic syndrome is associated with immüne inflammatory activation and alterations in platelet-related parameters. This study aimed to compare complete blood count parameters, platelet/mean platelet volüme related indicators, and hematological inflammatory indices between children with nephrotic syndrome and healthy controls, and to evaluate their relationship with steroid response and relapse frequency. Materials and Methods: This retrospective case-control study included 72 children with nephrotic syndrome and 40 healthy controls. Laboratory data obtained at the time of diagnosis, before steroid treatment, were analyzed. Complete blood count parameters, platelet/mean platelet volüme related indicators, and hematological inflammatory indices, including neutrophil-to-lymphocyte ratio, platelet-tolymphocyte ratio, monocyte-to-lymphocyte ratio, systemic immüne inflammation index, and systemic inflammatory response index, were evaluated. Patients with nephrotic syndrome were further classified as steroid sensitive or steroid resistant. Steroid sensitive patients were also compared according to relapse frequency. Results: Hemoglobin, white blood cell count, absolute neutrophil count, red cell distribution width, and platelet count were significantly higher in the nephrotic syndrome group than in the control group, whereas mean platelet volume was significantly lower. Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immüne inflammation index were also significantly higher in the nephrotic syndrome group. No significant differences were found between steroidsensitive and steroid resistant nephrotic syndrome groups in complete blood count parameters, platelet/mean platelet volüme related indicators, hematological inflammatory indices, or biochemical parameters. Among steroid sensitive patients, platelet count, platelet-to-lymphocyte ratio, and systemic immüne inflammation index were significantly higher in the frequent relapse group than in the infrequent relapse group. Correlation analyses showed limited associations, mainly between platelet count and albumin or total cholesterol levels. Conclusion: Complete blood count derived indices may provide practical supportive information regarding inflammatory and platelet related alterations in children with nephrotic syndrome. Platelet count, mean platelet volume, platelet-tolymphocyte ratio, and systemic immüne inflammation index differed particularly in patient control comparisons. At the same time, platelet related indices were also higher among steroid sensitive patients with frequent relapses. These parameters should be interpreted as complementary indicators rather than standalone diagnostic or prognostic markers.