Can second trimester monocyte to high-density lipoprotein ratio predict insulin requirement in gestational diabetes mellitus?
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, cilt.16, sa.1, ss.47-51, 2025 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.4328/acam.22388
- Dergi Adı: ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
- Sayfa Sayıları: ss.47-51
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Aim: Monocyte to high-density lipoprotein ratio is a new marker of chronic inflammation and oxidative stress, which plays a role in gestational diabetes. Here, we aimed to evaluate the second-trimester monocyte to high-density lipoprotein ratio in gestational diabetes and to assess the predictive role of insulin requirement and delivery mode in gestational diabetes. Material and Methods: A total of 45 gestational diabetes patients and 45 healthy pregnant were included in this retrospective study. The gestational diabetes group was divided into two subgroups: diet-controlled (n=15) and requiring insulin (n=30). Demographic and obstetrics characteristics, complete blood count, and biochemical analysis results were compared between groups. The predictive role of monocyte to high-density lipoprotein ratio for gestational diabetes, insulin requirement, and delivery mode was evaluated by receiver operating curve analysis. Results: The monocyte to high-density lipoprotein ratio was higher in gestational diabetes (p<0.001). Also, it was higher in insulin-requiring diabetes as compared to the controlled diabetes group (p=0.021). Monocyte to high-density lipoprotein ratio was correlated with fasting glucose (r=0.469, p=0.001) and 50-gram testing first-hour levels (r=0.595, p<0.001). Monocyte to high-density lipoprotein ratio >8.2 discriminated gestational diabetes with 91.1% sensitivity and 80% specificity (AUC=0.922, p<0.001), while >9.1 predicted insulin requirement with 86.7% sensitivity and 66.7% specificity (AUC=0.713,p=0.032). It did not predict cesarean section in gestational diabetes (p=0.21).
Discussion: The second-trimester monocyte to high-density lipoprotein ratio might be a cheap and available marker for detecting gestational diabetes and the insulin requirement in gestational diabetes mellitus.