The role of triple therapy, age, gender and smoking on the genotoxic effects of helicobacter pylori infection


Gulten T., Tokyay N., Demiray M., GÜLTEN M., ERCAN İ., Evke E., ...Daha Fazla

International Journal of Medicine, Biology and the Environment, cilt.29, sa.2, ss.155-158, 2001 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2001
  • Dergi Adı: International Journal of Medicine, Biology and the Environment
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.155-158
  • Anahtar Kelimeler: Age, Gender, Genotoxicity, Helicobacter pylori, Smoking, Therapy
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Helicobacter pylori (H. pylori) plays a major role in gastritis and is also considered as a carcinogen due to its genotoxic constitutive properties. Mutagenic and carcinogenic effects of genotoxic agents can be sensitively evaluated with sister chromatid exchange (SCE) analysis. Aim: We wanted to investigate the role of age, gender and smoking on the genotoxic effects of H. pylori and on the efficacy of the eradication therapy. Methods: Patients underwent endoscopy, biopsy and urease test for H. pylori before and after the treatment. Pre and post-treatment peripheral blood lymphocyte cultures were prepared from 17 patients with histologically and biochemically proven gastritis and H. pylori infection. From each patient 25 metaphases were analyzed for SCE. Results: Treatment eradicated H. pylori in patients (94%) and reduced significantly the SCE frequency. Pretreatment SCE frequency was found to be significantly increased in the elderly patients. Post-treatment SCE frequencies were higher in the group with high SCE frequencies to begin with. Women smokers had higher post-treatment SCE frequencies. Pre and post-treatment SCE frequencies were higher in the elderly males. Conclusion: eradication therapy decreased genotoxicity of H. pylori but age in males and smoking in females were found to be risk factors decreasing the efficacy of the treatment.