Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder

Armagan E., Almacioglu M. L., Yakut T., Kose A., Karkucak M., Koksal O., ...More

GENETICS AND MOLECULAR RESEARCH, vol.12, no.1, pp.852-858, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.4238/2013.march.19.1
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.852-858
  • Bursa Uludag University Affiliated: Yes


Alterations in catechol-O-methyltransferase (COMT) activity are involved in various types of neurological disorders. We examined a possible association between the COMT Val158Met polymorphism and conversion disorder in a study of 48 patients with conversion disorder and 48 control patients. In the conversion disorder group, 31 patients were Val/Met heterozygotes, 15 patients were Val/Val homozygotes and 2 patients were Met/Met homozygotes. In the control group, 32 patients were Val/Met heterozygotes and 16 patients were Val/Val homozygotes. There was no significant difference between the groups. We conclude that the COMT Val158Met genotype is quite common in Turkey and that it is not a risk factor for conversion disorder in the Turkish population.