Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder

Armagan E., Almacioglu M. L., Yakut T., Kose A., Karkucak M., Koksal O., ...Daha Fazla

GENETICS AND MOLECULAR RESEARCH, cilt.12, sa.1, ss.852-858, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.4238/2013.march.19.1
  • Dergi Adı: GENETICS AND MOLECULAR RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.852-858
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Alterations in catechol-O-methyltransferase (COMT) activity are involved in various types of neurological disorders. We examined a possible association between the COMT Val158Met polymorphism and conversion disorder in a study of 48 patients with conversion disorder and 48 control patients. In the conversion disorder group, 31 patients were Val/Met heterozygotes, 15 patients were Val/Val homozygotes and 2 patients were Met/Met homozygotes. In the control group, 32 patients were Val/Met heterozygotes and 16 patients were Val/Val homozygotes. There was no significant difference between the groups. We conclude that the COMT Val158Met genotype is quite common in Turkey and that it is not a risk factor for conversion disorder in the Turkish population.