MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats

Kocaeli H., Korfali E., Ozturk H., Kahveci N., Yilmazlar S.

SURGICAL NEUROLOGY, vol.64, pp.22-27, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64
  • Publication Date: 2005
  • Doi Number: 10.1016/j.surneu.2005.07.034
  • Journal Name: SURGICAL NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.22-27
  • Keywords: aorta, MK-801, neuroprotection, rat, spinal cord ischemia, thoracotomy, GLUTAMATE ANTAGONIST, INJURY, MODEL, PARAPLEGIA, PREVENTION, APOPTOSIS, DEFICITS
  • Bursa Uludag University Affiliated: Yes

Abstract

Background: Glutamergic excitotoxicity has been shown to play a deleterious role in the pathophysiology of ischemic spinal cord injury (ISCI). The aim of this study was to investigate the neuroprotective effect of a single dose of MK-801, an antiexcitotoxic drug, in a rat model of ISCI.