MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats

Kocaeli, H; Korfali, E; Ozturk, H; Kahveci, NEVZAT; Yilmazlar, SELÇUK

doi:10.1016/j.surneu.2005.07.034

MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats

Kocaeli H., Korfali E., Ozturk H., Kahveci N., Yilmazlar S.

SURGICAL NEUROLOGY, cilt.64, ss.22-27, 2005 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 64
Basım Tarihi: 2005
Doi Numarası: 10.1016/j.surneu.2005.07.034
Dergi Adı: SURGICAL NEUROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.22-27
Anahtar Kelimeler: aorta, MK-801, neuroprotection, rat, spinal cord ischemia, thoracotomy, GLUTAMATE ANTAGONIST, INJURY, MODEL, PARAPLEGIA, PREVENTION, APOPTOSIS, DEFICITS
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Glutamergic excitotoxicity has been shown to play a deleterious role in the pathophysiology of ischemic spinal cord injury (ISCI). The aim of this study was to investigate the neuroprotective effect of a single dose of MK-801, an antiexcitotoxic drug, in a rat model of ISCI.