MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats


Kocaeli H., Korfali E., Ozturk H., Kahveci N., Yilmazlar S.

SURGICAL NEUROLOGY, cilt.64, ss.22-27, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.surneu.2005.07.034
  • Dergi Adı: SURGICAL NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.22-27
  • Anahtar Kelimeler: aorta, MK-801, neuroprotection, rat, spinal cord ischemia, thoracotomy, GLUTAMATE ANTAGONIST, INJURY, MODEL, PARAPLEGIA, PREVENTION, APOPTOSIS, DEFICITS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Glutamergic excitotoxicity has been shown to play a deleterious role in the pathophysiology of ischemic spinal cord injury (ISCI). The aim of this study was to investigate the neuroprotective effect of a single dose of MK-801, an antiexcitotoxic drug, in a rat model of ISCI.