Vitamin D, VDR and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients

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Atıf İçin Kopyala

Ellergezen P., Alp A., Çavun S.

Medical records-international medical journal (Online), cilt.5, sa.1, ss.24-28, 2022 (Hakemli Dergi)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 5 Sayı: 1
• Basım Tarihi: 2022
• Doi Numarası: 10.37990/medr.1131305
• Dergi Adı: Medical records-international medical journal (Online)
• Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.24-28
• Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Aim: The major target of this research is to examine whether there is any connection between the levels of vitamin D and antiinflammatory

mediators in patients with fibromyalgia syndrome (FMS).

Materials and Methods: The study contains 30 FMS diagnosed and 25 healthy female individuals and the determination of FMS was

made according to the standards of 2010 American College of Rheumatology (ACR). Vitamin D, vitamin D receptor (VDR), vitamin D

binding protein (VDBP) levels, and anti-inflammatory cytokine (IL-4, IL-10, TGF-β) levels in the serum of patients with FMS and healthy

individuals were measured using enzyme-linked immunosorbent assay (ELISA).

Results: The concentrations of vitamin D, VDR, and VDBP were determined to be higher in healthy controls than in patients with FMS

(p<0.001). Correlating with this, IL-4, IL-10, and TGF-β levels were measured remarkably higher in the healthy group than in the FMS

patients (p<0.001).

Conclusion: Low vitamin D levels may cause a decrease in anti-inflammatory cytokine levels and their immunosuppressive effect in

FMS.