Akademik Veri Yönetim Sistemi
East Black Sea Journal of Health Sciences, sa.2, ss.127-140, 2023 (Hakemli Dergi)
Purpose: Today, cancer; It is attempted to be treated using methods such as surgical methods, chemotherapy, radiotherapy, bone marrow, stem cell transplantation, immunotherapy, hormone and antibody therapy. Each method has its own advantages and disadvantages. One of the side effects caused by chemotherapeutic drugs is that they cause redness, swelling, itching and numbness in the hands and feet of patients. Especially during this side effect process, the loss of fingerprints causes important criminal problems. In this study, cancer drugs that cause hand-foot syndrome were examined and their effects were tried to be explained.
Material method: Articles, electronic books, journals and theses were examined through different databases.
Findings and results: In the study, the active substances of the drugs used in chemotherapy, which cause redness in the palmar and plantar regions and cause burning and sensation in the hands and feet, are presented in tables. These substances include, primarily capecitabine, cabozantinib, pazopanib, vemurafenib, axitinib, doxorubicin, sunitinib, regorafenib, docetaxel and sorafenib. The metabolic pathway that causes hand-foot syndrome is still unexplained.