Efficacy of antiseptic-impregnated catheters on catheter colonization and catheter-related bloodstream infections in patients in an intensive care unit

Osma S., Kahveci S., Kaya F., Akalin H., Ozakin C., Yilmaz E., ...More

JOURNAL OF HOSPITAL INFECTION, vol.62, no.2, pp.156-162, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1016/j.jhin.2005.06.030
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.156-162
  • Keywords: central venous catheters, antiseptic-impregnated catheters, catheter colonization, catheter-related bloodstream infection, CENTRAL VENOUS CATHETERS, SILVER-SULFADIAZINE, BACTERIAL-COLONIZATION, CONTROLLED TRIAL, PREVENTION, SEPSIS, CHLORHEXIDINE, PATHOGENESIS, CULTURES
  • Bursa Uludag University Affiliated: Yes


SThis study was conducted to evaluate the impact of central venous catheters impregnated with chlorhexidine and silver sulphadiazine on the incidence of colonization and catheter-related bloodstream infection in critically ill patients. One hundred and thirty-three patients requiring central venous catheterization were chosen at random to receive either an antiseptic-impregnated triple-lumen catheter (N = 64) or a standard triple-lumen catheter (N = 69). The mean (SD) durations of catheterization for the antiseptic and standard catheters were 11.7 (5.8) days (median 10; range 3-29) and 8.9 (4.6) days (median 8.0; range 3-20), respectively (P = 0.006). Fourteen (21.9%) of the antiseptic catheters and 14 (20.3%) of the standard catheters had been colonized at the time of removal. (P = 0.834). Four cases (6.3%) of catheter-related bloodstream infection were associated with antiseptic catheters and one case (1.4%) was associated with a standard catheter (P = 0.195). The catheter colonization rates were 18.7/1000 catheter-days for the antiseptic catheter group and 22.6/1000 catheter-days for the standard catheter group (P = 0.640). The catheter-related bloodstream infection rates were 5.3/1000 catheter-days for the antiseptic catheter group and 1.6/1000 catheter-days for the standard catheter group (P = 0.452). In conclusion, our results indicate that the use of antiseptic-impregnated central venous catheters has no effect on the incidence of either catheter colonization or catheter-related bloodstream infection in critically ill patients. (c) 2005 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.