Effects of Combination Therapy with Captopril and Angiotensin II on the Viability of Random-pattern Skin Flaps in Diabetic Rat Model

Aygoren B. H., ÖZ ATALAY F., AYTAÇ VURUŞKAN B., AKIN S.

TURKISH JOURNAL OF PLASTIC SURGERY, cilt.24, sa.4, ss.190-196, 2016 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/turkjplastsurg.2016.2077
  • Dergi Adı: TURKISH JOURNAL OF PLASTIC SURGERY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.190-196
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: Diabetes mellitus leads to tissue damage by erythrocyte aggregation and an endothelial dysfunction-mediated disturbance in vascularization. These mechanisms facilitate the formation of skin wounds. As skin flaps are often used in the treatment of diabetic wounds, enhancing the blood supply and lowering blood glucose levels have emerged as important factors to increase the success of treatment using skin flaps. Therefore, in this study, the effectiveness of captopril and angiotensin II treatments were investigated to determine if they increased blood flow to skin flaps to protect their viability in an experimental diabetic rat model.