The Role of the Dopamine beta-hydroxylase Functional Polymorphism in Patients with Early-Onset Parkinson's Disease in the Turkish Population

Erer, ÇİĞDEM; Eryılmaz, IŞIL; Colak, Dilara; Egeli, ÜNAL; Çeçener, GÜLŞAH; Tunca, BERRİN; Karakus, Ece; Colakoglu, Beril; Tokcaer, Ayse; Saka, Esen; Demirkiran, Meltem; Akbostanci, Cenk; Zarifoğlu, MEHMET; Doğu, Okan; Kaleagasi, Hakan; Kenangil, Gulay; Cakmur, Raif; Elibol, Bülent

doi:10.4274/tnd.2020.80633

The Role of the Dopamine beta-hydroxylase Functional Polymorphism in Patients with Early-Onset Parkinson's Disease in the Turkish Population

Erer S., Eryılmaz I. E., Colak D. K., Egeli Ü., Çeçener G., Tunca B., ...Daha Fazla

TURKISH JOURNAL OF NEUROLOGY, cilt.27, sa.1, ss.21-26, 2021 (ESCI, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 27 Sayı: 1
Basım Tarihi: 2021
Doi Numarası: 10.4274/tnd.2020.80633
Dergi Adı: TURKISH JOURNAL OF NEUROLOGY
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.21-26
Anahtar Kelimeler: Early-onset Parkinson's disease, dopamine beta-hydroxylase (DBH), polymorphism, Turkish population
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: A functional single nucleotide polymorphism, rs1611115, in the dopamine beta-hydroxylase (DBH) gene, is reported to regulate plasma enzyme activity levels. Mere, we report the first evaluation of this association in patients with early-onset Parkinson's disease (EOPD) and healthy controls in the Turkish population.