Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism.

YenmİŞ, GÜven; BeŞlİ, Naİl; Yaprak SaraÇ, Elİf; HocaoĞlu Emre, Fatma; Şenol, KAZIM; KanigÜr, GÖnÜl

doi:10.3906/sag-1908-112

Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism.

YenmİŞ G., BeŞlİ N., Yaprak SaraÇ E., HocaoĞlu Emre F. S., Şenol K., KanigÜr G.

Turkish journal of medical sciences, cilt.51, ss.826-834, 2021 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 51
Basım Tarihi: 2021
Doi Numarası: 10.3906/sag-1908-112
Dergi Adı: Turkish journal of medical sciences
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.826-834
Anahtar Kelimeler: AMPK-alpha, cyclin D1, Tp53, breast cancer, metformin, ACTIVATED PROTEIN-KINASE, IN-VITRO, PROLIFERATION, ARREST, GROWTH, VIVO
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background/aim: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer cells (PBCCs).