Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism.

YenmİŞ G., BeŞlİ N., Yaprak SaraÇ E., HocaoĞlu Emre F. S., Şenol K., KanigÜr G.

Turkish journal of medical sciences, vol.51, pp.826-834, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-1908-112
  • Journal Name: Turkish journal of medical sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.826-834
  • Keywords: AMPK-alpha, cyclin D1, Tp53, breast cancer, metformin, ACTIVATED PROTEIN-KINASE, IN-VITRO, PROLIFERATION, ARREST, GROWTH, VIVO
  • Bursa Uludag University Affiliated: Yes

Abstract

Background/aim: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer cells (PBCCs).