Characteristics Predicting Tuberculosis Risk under Tumor Necrosis Factor-α Inhibitors: Report from a Large Multicenter Cohort with High Background Prevalence.


Kisacik B., Pamuk O. N. , Onat A. M. , Erer S. B. , Hatemi G., Ozguler Y., ...More

The Journal of rheumatology, vol.43, no.3, pp.524-9, 2016 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.3899/jrheum.150177
  • Title of Journal : The Journal of rheumatology
  • Page Numbers: pp.524-9
  • Keywords: TUMOR NECROSIS FACTOR-A INHIBITORS, TUBERCULOSIS REACTIVATION, ISONIAZID, RHEUMATOID-ARTHRITIS, FACTOR ANTAGONISTS, THERAPY, TNF, MORTALITY, INFECTIONS, TERM

Abstract

Objective. Screening strategies for latent tuberculosis (TB) before starting tumor necrosis factor (TNF)-alpha inhibitors have decreased the prevalence of TB among patients who are treated with these agents. However, despite vigilant screening, TB continues to be an important problem, especially in parts of the world with a high background TB prevalence. The aim of this study was to determine the factors related to TB among a large multicenter cohort of patients who were treated with anti-TNF.