Stimulus properties of venlafaxine in a conditioned taste aversion procedure

Kayir H., Alici T., Goktalay G., Yildirim M., Ulusoy G. K., Ceyhan M., ...More

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.596, pp.102-106, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 596
  • Publication Date: 2008
  • Doi Number: 10.1016/j.ejphar.2008.08.015
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.102-106
  • Keywords: Conditioned taste aversion, Antidepressant, Venlafaxine, Tianeptine, Fluoxetine, Escitalopram, Reboxetine, L-NAME, (Mice), SEROTONIN REUPTAKE INHIBITOR, DISCRIMINATIVE STIMULUS, ANTIDEPRESSANT, CITALOPRAM, DRUGS
  • Bursa Uludag University Affiliated: Yes


Conditioned stimulus properties of venlafaxine are still unknown. In the present study, the discriminative stimulus properties of venlafaxine by using a conditioned taste aversion procedure were investigated. Swiss Webster mice were allowed to reach water from 2 pipettes for 20 min (09:00-11:30 h), plus 30 min (15:3016:00 h), daily. During the 4 days, the test drugs [fluoxetine, escitalopram, tianeptine, reboxetine, and N omega-nitro-L-arginine methyl ester(L-NAME)l were injected to mice at least 1 h after they had first water session. On day 5, they consumed glucose solution(5%w/v) and immediately injected with conditioning drug (venlafaxine 32 mg/kg). On day 8, mice were allowed to make a choice between water and glucose solution. The amount of glucose consumption as a percentage of total fluid intakes was calculated for each animal. Significant reduction in glucose choice was defined as conditioned taste aversion. Venlafaxine (32 mg/kg) induced a robust conditioned taste aversion in mice. Pre-exposure to tianeptine (2.5-10 mg/kg), fluoxetine (10 mg/kg), escitalopram (32 mg/kg), and reboxetine (5 mg/kg) substituted for venlafaxine by preventing the conditioned taste aversion induced by venlafaxine. L-NAME did not substitute for venlafaxine. Substitution of venlafaxine by fluoxetine, tianeptine, escitalopram, and reboxetine provides further evidence that both 5-HT and noradrenaline reuptake inhibition may play an important role in the stimulus effect of venlafaxine. (C) 2008 Elsevier B.V. All rights reserved.