Overexpression of CK20, MAP3K8 and EIF5A correlates with poor prognosis in early-onset colorectal cancer patients

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TUNCA B., Tezcan G., ÇEÇENER G., EGELİ Ü., Zorluoglu A., Yilmazlar T., ...More

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.139, no.4, pp.691-702, 2013 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 139 Issue: 4
• Publication Date: 2013
• Doi Number: 10.1007/s00432-013-1372-x
• Journal Name: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.691-702
• Keywords: Colorectal cancer, CK20, MAP3K8, EIF5A, Poor prognosis, Turkish population, INOSINE MONOPHOSPHATE DEHYDROGENASE, GENOMIC HYBRIDIZATION REVEALS, SQUAMOUS-CELL CARCINOMA, INDEPENDENT PREDICTOR, EXPRESSION, CYTOKERATIN-20, EIF-5A2, YOUNG, GENE, AGE
• Bursa Uludag University Affiliated: Yes

Abstract

Due to ethnic, genetic and environmental factors, the clinical and molecular characteristics of Turkish colorectal cancer (CRC) patients are different from those of Western populations. The aim of this study was to clarify the relevant alterations of gene expression associated with colorectal carcinogenesis in early-onset patients and to identify specific biomarkers that could provide novel therapeutic molecular targets in this population.