The significance of fine needle aspiration biopsy in diagnosis of pancreatic lesions Pankreas lezyonlarinin tanisinda ince igne aspirasyon biyopsisinin yeri

YERCİ Ö., GÜREL S., Ozturk H., Dolar E., BALABAN S., ORHAN B., ...More

Turkish Journal of Gastroenterology, vol.10, no.4, pp.367-371, 1999 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 1999
  • Journal Name: Turkish Journal of Gastroenterology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.367-371
  • Bursa Uludag University Affiliated: Yes


Fine needle aspiration biopsy (FNAB) has a diagnostic value of nearly 100% in the discrimination of malignant and benign pancreatic lesions identified by radiologic methods. This study evaluated the results of cases in which ultrasound (US) guided percutaneous FNAB had been performed during the previous three years. One hundred and one FNABs taken from 86 patients at Uludag University Faculty of Medicine Department of Gastroenterology and Radiology are included, 46 (53.4%) of which were diagnosed as malignant. Among the malignant cases, 31 (67.3%) were male, 15 (32.7%) were female and the M/F ratio was 2.06. Age ranged between 28 and 88 years and the mean age was 58.5 years. Nucleomegalia, nuclear prominence, nuclear membrane irregularities, nuclear crowding, anisonucleosis, necrosis and mitosis were accepted and evaluated as the criteria of malignancy. Thirty nine of the malignant cases were adenocarcinoma, asinic cell carcinoma, 2 small cell carcinoma (one of them being lung as the primary), 1 anaplastic large cell carcinoma, 1 islet cell carcinoma and 1 non-Hodgkin lymphoma. The localization of the tumour was head of the pancreas in 36 cases (78.3%), corpus in 8 (17.4%) and tail in 2 (4.3%). The material was insufficient for diagnosis in 18 cases (17.8%). In 21 of the cases, normal pancreatic cells were observed. There were 11 acute pancreatitis (10.9%) and 5 chronic pancreatitis (4.9%). We concluded that US guided FNAB is a very easily performed and reliable method of diagnosing pancreatic malignancies.