Un-methylation of the survivin gene has no effect on immunohistochemical expression of survivin protein in lung cancer patients with squamous cell carcinoma

Yalcin, O.; Budak, M.

doi:10.4149/bll_2017_032

Un-methylation of the survivin gene has no effect on immunohistochemical expression of survivin protein in lung cancer patients with squamous cell carcinoma

Atıf İçin Kopyala

Yalcin O., Budak M.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.118, sa.3, ss.160-163, 2017 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 118 Sayı: 3
Basım Tarihi: 2017
Doi Numarası: 10.4149/bll_2017_032
Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.160-163
Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

Survivin is a member of the inhibitor of apoptosis (IAP) family. The function of the survivin protein is to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by the disruption of survivin induction pathways leading to an increased apoptosis and decreased tumour growth. These data suggest that survivin may provide a new target for cancer treatment, which would distinguish transformed cells from normal cells.