Neurofibromatosis type 1 is a common neurogenetic disorder. Psychiatric disorders are more common in patients with neurofibromatosis type 1 than the general population. Here we report a neurofibromatosis type 1 patient associated with generalised anxiety disorder. Although the patient is under psychiatric follow-up for approximately 15 years her dermatological complaints has been ignored. Because of this, dermatological lesions that are persisting over 40 years, the patient did not diagnosed as Neurofibromatosis type 1, in case social, pyshcologic and biologic complaints associated with Neurofibromatosis type 1 is ignored. It is clear that the history of the patient was not understood as a whole and she was exposed to use of antipsychotics in an inappropriate way. Because of using antipsychotics tardive dyskinesia occured in this patient and this reminds us to be more careful while prescribing medicines. It should be noted that human is a biopsychosocial entity and biologic, psychologic and social factors play role during the illness process. Physcians should evaluate their patients as a whole, not only their complaints and family history for not missing any medical condition.