Anti-angiogenic effect of a Palladium(II)-Saccharinate Complex of Terpyridine in vitro and in vivo


Ikitimur-Armutak E. I. , Gurel-Gurevin E., KIYAN H. T. , Aydinlik S., YILMAZ V. T. , Dimas K., ...More

MICROVASCULAR RESEARCH, vol.109, pp.26-33, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 109
  • Publication Date: 2017
  • Doi Number: 10.1016/j.mvr.2016.09.002
  • Title of Journal : MICROVASCULAR RESEARCH
  • Page Numbers: pp.26-33
  • Keywords: Palladium(II)-Saccharinate Complex of, Terpyridine, Anti-angiogenic, Chick chorioallantoic membrane (CAM) assay, MTT assay, Tube formation assay, CHORIOALLANTOIC MEMBRANE, PLATINUM(II) COMPLEXES, CYTOTOXIC ACTIVITY, CANCER, ANTITUMOR, CHEMOTHERAPY, ANTIFUNGAL, MODEL

Abstract

Anti-angiogenic activity of palladium (Pd) (II)-based complexes is unknown despite their quite powerful anticancer activity. This study was therefore carried out to evaluate both in vivo anti-angiogenic effect and in vitro cytotoxic activity of a Pd(II)-based complex. ([Pd(sac)(terpy)](sac).4H(2)O(sac = saccharinate and terpy = 2,2':6',2 ''-terpyridine)) on HUVEC cells.