Hydatid disease in acute leukemia: effect of anticancer treatment on echinococcosis

Ali R., Ozkalemkas F., Ozkocaman V., Ozcelik T., Akalin H., Ozkan A., ...More

MICROBES AND INFECTION, vol.7, pp.1073-1076, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2005
  • Doi Number: 10.1016/j.micinf.2005.02.015
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1073-1076
  • Keywords: hydatid disease, echinococcosis, cystic echinococcosis, acute leukemia, cancer, anticancer treatment, ALBENDAZOLE, CYSTS
  • Bursa Uludag University Affiliated: Yes


Echinococcosis, also known as hydatid disease or hydatidosis, is a zoonotic illness caused by the larval form of Echinococcus spp. It is highly prevalent in areas where the parasite is endemic such as the Mediterranean region. However, occurrence of echinococcosis and cancer together is rare. We treated and followed approximately 1200 patients with different hematologic neoplastic diseases between 1985 and 2003, and only one of these individuals had concomitant acute leukemia and liver hydatidosis. This report describes the case of a 19-year-old man who had both primary refractoriness of acute leukemia (AML-M-4) and liver hydatidosis. Management is discussed. The patient had cystic echinococcosis (CE) of the liver that was classified as CE1 according to the system established by the World Health Organization's Informal Working Group on Echinococcosis. The patient underwent 3 months of treatment with agents that targeted the leukemia (daunorubicin, idarubicin, cytarabine, fludarabine) and its complications (amphotericin B, amphotericin B lipid complex, liposomal amphotericin B). Throughout this period, the size and the contents of the cyst did not change, Echinococcus titers remained unchanged, and the cyst classification remained CE1. (C) 2005 Elsevier SAS. All rights reserved.