Pancreas, vol.45, no.9, pp.1294-302, 2016 (Peer-Reviewed Journal)
Article / Article
Science Citation Index Expanded, Scopus
pancreatic ductal adenocarcinoma, EGFR, KRAS, miR-216b, FGFR1, radiotherapy resistance, COLORECTAL-CANCER, GEMCITABINE, PROGRESSION, METASTASIS, INHIBITION, MICRORNAS, PROGNOSIS, CARCINOMA, INVASION, IMPACT
Objectives: The success of gemcitabine plus radiotherapy is dependent on the mutation status of pancreatic ductal adenocarcinoma (PDAC) tumors in the EGFR and KRAS genes; however, radiotherapy resistance may also be modulated epigenetically by microRNA (miRNA) regulation. In this study, we examined the potential effect of miRNAs on the resistance to radiotherapy in cases without EGFR or KRAS mutation.