Pathological abnormalities after long-term administration of medroxyprogesterone acetate in a queen

KESKİN A., MECİTOĞLU G., Yilmaz R., ÖZYİĞİT M. Ö., GÜMEN A.

Journal of Feline Medicine and Surgery, cilt.11, sa.6, ss.518-521, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.jfms.2008.10.006
  • Dergi Adı: Journal of Feline Medicine and Surgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.518-521
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

In this report, multiple abnormalities (bilateral ovarian cysts, cystic endometrial hyperplasia and pyometra (CEH-P), mammary adenoma, fibrosarcoma and cystic-papillary adenocarcinoma) identified in a queen continually administered medroxyprogesterone acetate (MPA) for 9 years are described. An 11-year-old domestic shorthair intact queen was presented for reduced appetite, polyuria, polydipsia, abdominal distension, and mammary mass. Pyometra was diagnosed based upon clinical, ultrasonographic and radiographic examinations. Mastectomy and ovariohysterectomy (OHE) were performed for treatment. Bilateral ovarian cysts were detected during OHE. Histopathologically, follicular ovarian cysts, CEH-P, and benign and neoplastic mammary lesions were identified. We suggest that, the pathological abnormalities may have been attributed to adverse effects of prolonged administration of MPA. © 2008 ESFM and AAFP.