Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, vol.32, no.1, pp.33-39, 2004 (Scopus)
In this study we aimed to compare the efficiency and safety of thiopentone and propofol to provide sedation in children undergoing computerized tomography (CT) scanning. Eighty ASA I-II children 2-8 years old, scheduled for CT scanning were included in the study. Patients were randomly divided into 2 groups regarding the use of thiopentone or propofol for sedation. In group T, patients were given 2 mg kg-1 thiopentone intravenously as bolus doses. In group P, patients received 1 mg kg-1 propofol and then propofol infusion was started at 4-8 mg kg-1 hr-1. The patients' peripheral oxygen saturation, respiratory rate and noninvasive blood pressure were monitored during the procedure. After completion of the CT scanning, the cases were evaluated for recovery criteria and for side effects before discharging. We did not find any significant differences between the two groups regarding mean blood pressure, heart rate, peripheral oxygen saturation and respiratory rate during the CT scanning (p>0.05). No severe respiratory depression or desaturation (SpO2<95%) was detected. We found that in propofol group recovery and discharge times were significantly shorter than in thiopentone group (p<0.0001) and the incidence of side effects was significantly higher in thiopentone group (p<0.05). In conclusion, as a result of comparison of the propofol infusion and thiopentone boluses for sedation in pediatric cases, we obtained a better recovery time and a lower side effect incidence in propofol group.