Divergent PET Tracer Avidity in Synchronous Sarcomatoid Carcinoma With Osteosarcomatous Differentiation and Adenocarcinoma of the Prostate: Insights From Dual-Tracer 68 Ga-PSMA and 18 F-FDG PET/CT Imaging
Clinical nuclear medicine, vol.51, no.9, pp.813-814, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 51 Issue: 9
- Publication Date: 2026
- Doi Number: 10.1097/rlu.0000000000006576
- Journal Name: Clinical nuclear medicine
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Page Numbers: pp.813-814
- Keywords: dual-tracer PET/CT, prostate cancer, sarcomatoid carcinoma, tumor heterogeneity
- Bursa Uludag University Affiliated: Yes
Abstract
A 76-year-old man with mildly elevated prostate-specific antigen (PSA, 5.44ng/mL) and a PI-RADS 5 lesion on multiparametric MRI underwent dual-tracer PET/CT. 68 Ga-PSMA PET/CT revealed focal intense uptake in one prostatic lobe, while 18 F-FDG PET/CT demonstrated avid uptake in the contralateral lobe. Histopathology confirmed synchronous high-grade prostatic adenocarcinoma (Gleason 9) and sarcomatoid carcinoma with osteosarcomatous differentiation. This discordant dual-tracer pattern highlights the complementary role of PSMA and FDG PET/CT in detecting molecularly divergent synchronous prostatic malignancies.