Impact of Genetic Variants in Human Scavenger Receptor Class B Type I (SCARB1) on Plasma Lipid Traits


Niemsiri V., Wang X., PİRİM D., Radwan Z. H. , Hokanson J. E. , Hamman R. F. , ...More

CIRCULATION-CARDIOVASCULAR GENETICS, vol.7, no.6, pp.838-898, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1161/circgenetics.114.000559
  • Journal Name: CIRCULATION-CARDIOVASCULAR GENETICS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.838-898
  • Keywords: genetic association studies, genetic variation, haplotypes, lipids, polymorphism, genetic, SCARB1 protein, human, sequence analysis, DNA, HIGH-DENSITY-LIPOPROTEIN, HDL-CHOLESTEROL, SR-BI, TRANSGENIC MICE, ASSOCIATION, METABOLISM, APOLIPOPROTEINS, OVEREXPRESSION, DISEASE, RISK

Abstract

Background-Scavenger receptor class B type 1 (SCARB1) plays an important role in high-density lipoprotein cholesterol (HDL-C) metabolism in selective cholesteryl ester uptake and in free cholesterol cellular efflux.