Impact of Genetic Variants in Human Scavenger Receptor Class B Type I (SCARB1) on Plasma Lipid Traits

Niemsiri, Vipavee; Wang, Xingbin; PİRİM, DİLEK; Radwan, Zaheda; Hokanson, John; Hamman, Richard; Barmada, M.; Demirci, F.; Kamboh, M.

doi:10.1161/circgenetics.114.000559

Impact of Genetic Variants in Human Scavenger Receptor Class B Type I (SCARB1) on Plasma Lipid Traits

Niemsiri V., Wang X., PİRİM D., Radwan Z. H., Hokanson J. E., Hamman R. F., ...More

CIRCULATION-CARDIOVASCULAR GENETICS, vol.7, no.6, pp.838-898, 2014 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 7 Issue: 6
Publication Date: 2014
Doi Number: 10.1161/circgenetics.114.000559
Journal Name: CIRCULATION-CARDIOVASCULAR GENETICS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.838-898
Keywords: genetic association studies, genetic variation, haplotypes, lipids, polymorphism, genetic, SCARB1 protein, human, sequence analysis, DNA, HIGH-DENSITY-LIPOPROTEIN, HDL-CHOLESTEROL, SR-BI, TRANSGENIC MICE, ASSOCIATION, METABOLISM, APOLIPOPROTEINS, OVEREXPRESSION, DISEASE, RISK
Bursa Uludag University Affiliated: No

Abstract

Background-Scavenger receptor class B type 1 (SCARB1) plays an important role in high-density lipoprotein cholesterol (HDL-C) metabolism in selective cholesteryl ester uptake and in free cholesterol cellular efflux.