Synthesis of Furo[2,3-d]pyridazin-4(5H)-one and Its N(5)-Substituted Derivatives


Creative Commons License

Karahan E., Koza G. , Balci M.

HELVETICA CHIMICA ACTA, vol.97, pp.1487-1496, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 97
  • Publication Date: 2014
  • Doi Number: 10.1002/hlca.201400042
  • Title of Journal : HELVETICA CHIMICA ACTA
  • Page Numbers: pp.1487-1496

Abstract

We report the efficient preparation of furo[2,3-d] pyridazin-4(5H)-one and its N-substituted derivatives starting from methyl 2-methylfuran-3-carboxylate. The Me group was converted to the aldehyde group, which was then condensed with hydrazine derivatives. Then, the ester functionalities were hydrolyzed to the corresponding acids, followed by treatment with SOCl2 to give N-substituted furopyridazinone derivatives.