Synthesis of Furo[2,3-d]pyridazin-4(5H)-one and Its N(5)-Substituted Derivatives

Creative Commons License

Karahan E., Koza G., Balci M.

HELVETICA CHIMICA ACTA, cilt.97, ss.1487-1496, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 97
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1002/hlca.201400042
  • Dergi Adı: HELVETICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1487-1496
  • Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

We report the efficient preparation of furo[2,3-d] pyridazin-4(5H)-one and its N-substituted derivatives starting from methyl 2-methylfuran-3-carboxylate. The Me group was converted to the aldehyde group, which was then condensed with hydrazine derivatives. Then, the ester functionalities were hydrolyzed to the corresponding acids, followed by treatment with SOCl2 to give N-substituted furopyridazinone derivatives.