Surgical and Oncologic Outcomes of Colorectal Cancer Across Age Groups:A Multicenter Retrospective Study from the Turkish Society of Colon and Rectal Surgery Registry
Turkish Journal of Colorectal Disease, vol.35, pp.151-154, 2025 (Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 35
- Publication Date: 2025
- Doi Number: 10.4274/tjcd.galenos.2025.2025-6-1
- Journal Name: Turkish Journal of Colorectal Disease
- Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.151-154
- Keywords: age stratification, clinicopathological, Colorectal cancer, colorectal surgery, elderly, neoadjuvant therapy, postoperative complications
- Bursa Uludag University Affiliated: Yes
Abstract
Aim: This study aimed to perform a comparative analysis of colorectal surgery outcomes in elderly versus younger age groups of patients with colorectal cancer (CRC). Method: A total of 1.216 patients who underwent colorectal surgery for malignancy were included in this retrospective database study. Data on preoperative characteristics and operative, postoperative, and histopathological parameters were compared across age groups (<50 years, 50-64 years, 65-79 years, and >80 years). Results: The >80 years age group, when compared with younger age groups, was associated with the highest preoperative carcinoembryonic antigen levels (p<0.01) and higher rates of American Society of Anesthesiologists physical status 3 (45.3% vs. 3.4% in <50 years, 11.0% in 50-64 years, and 26.5% in 65-79 years, p<0.001), urgent surgery (16.3% vs. 7.0% in 65-79 years and 5.9% in 50-64 years, p=0.009), tumor perforation (9.3% vs. 2.9% in 65-79 years, p=0.031), and not receiving preoperative neoadjuvant therapy (p<0.001). In both the >80 years and 65-79 years age groups, colon cancer was significantly more prevalent (p<0.001), whereas pelvic magnetic resonance imaging (p<0.001) and positron emission tomography/computed tomography utilization (p<0.001) were less common than in younger age groups. No significant difference was noted between age groups in terms of surgical approach, length of operating time, postoperative complications, tumor clinicopathology, and regression scores. Conclusion: Adopting a transdisciplinary model of care that incorporates comprehensive geriatric assessment tools is important to optimize surgical care in elderly patients with CRC, as appropriately selected individuals can achieve excellent outcomes when managed according to the same standards applied to younger patients.