High-dose taurine supplementation increases serum paraoxonase and arylesterase activities in experimental hypothyroidism


Dirican M., Tas S., Sarandol E.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.34, no.9, pp.833-837, 2007 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 9
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1440-1681.2007.04615.x
  • Journal Name: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.833-837
  • Keywords: arylesterase, hypothyroidism, lipid, oxidative stress, paraoxonase, taurine, LOW-DENSITY-LIPOPROTEIN, DIETARY TAURINE, OXIDATIVE STRESS, LIPID-PEROXIDATION, LIVER CHOLESTEROL, RATS, METABOLISM, PLASMA, DEGRADATION, PROTECTION

Abstract

Hypothyroidism is accompanied by hyperlipidaemia and oxidative stress and is associated with several complications, such as atherosclerosis. Paraoxonase activity has been reported to decrease in several situations associated with atherosclerosis and oxidative stress. In the present study, the effects of different doses of taurine on serum paraoxonase and arylesterase activities, as well as on the serum lipid profile, were investigated in hypothyroid rats.