Analysis of TNF-alpha G308A and C857T Gene Polymorphisms in Turkish Patients with Obstructive Sleep Apnea Syndrome
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.32, sa.5, ss.1368-1373, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 5
- Basım Tarihi: 2012
- Doi Numarası: 10.5336/medsci.2012-28126
- Dergi Adı: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1368-1373
- Anahtar Kelimeler: Polymorphism, single nucleotide, sleep apnea, obstructive, ANGIOTENSIN-CONVERTING ENZYME, CARDIOVASCULAR-DISEASE, PROMOTER POLYMORPHISM, ASSOCIATION, CYTOKINES, OBESITY, ARTHRITIS, ALLELES, REGION
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Objective: Tumor necrosis factor-alpha (TNF-alpha) is an important indicator of inflammation. Recent studies have demonstrated a relationship between inflammation and obstructive sleep apnea syndrome (OSAS). The aim of this study was to investigate the association between TNF-alpha G308A and C857T gene polymorphisms and OSAS in Turkish patients. Material and Methods: Sixty-nine patients who were diagnosed with OSAS and 42 control subjects were included in the study. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect TNF-alpha G308A and C857T gene polymorphisms. The level of significance for statistical analysis was set at p<0.05. Results: The distribution of genotypes was not significantly different between subjects with a definite diagnosis of OSAS and the control group (p> 0.05). However, the mean body mass index of the OSAS group was significantly different from that of the control group (p<0.05). Conclusion: To our knowledge, this study is the first to analyze the relationship between OSAS and INF-alpha G308A and C857T gene polymorphisms in Turkish patients. Our results do not support an association between OSAS and TNF-alpha G308A and C857T gene polymorphisms.