Analysis of TNF-alpha G308A and C857T Gene Polymorphisms in Turkish Patients with Obstructive Sleep Apnea Syndrome


Karkucak M., URSAVAŞ A., OCAKOĞLU G., Gorukmez O., Yakut T., ERCAN İ., ...More

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.32, no.5, pp.1368-1373, 2012 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.5336/medsci.2012-28126
  • Journal Name: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1368-1373
  • Keywords: Polymorphism, single nucleotide, sleep apnea, obstructive, ANGIOTENSIN-CONVERTING ENZYME, CARDIOVASCULAR-DISEASE, PROMOTER POLYMORPHISM, ASSOCIATION, CYTOKINES, OBESITY, ARTHRITIS, ALLELES, REGION

Abstract

Objective: Tumor necrosis factor-alpha (TNF-alpha) is an important indicator of inflammation. Recent studies have demonstrated a relationship between inflammation and obstructive sleep apnea syndrome (OSAS). The aim of this study was to investigate the association between TNF-alpha G308A and C857T gene polymorphisms and OSAS in Turkish patients. Material and Methods: Sixty-nine patients who were diagnosed with OSAS and 42 control subjects were included in the study. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect TNF-alpha G308A and C857T gene polymorphisms. The level of significance for statistical analysis was set at p<0.05. Results: The distribution of genotypes was not significantly different between subjects with a definite diagnosis of OSAS and the control group (p> 0.05). However, the mean body mass index of the OSAS group was significantly different from that of the control group (p<0.05). Conclusion: To our knowledge, this study is the first to analyze the relationship between OSAS and INF-alpha G308A and C857T gene polymorphisms in Turkish patients. Our results do not support an association between OSAS and TNF-alpha G308A and C857T gene polymorphisms.