Plasma Chymase Activity Reflects the Change in Hemodynamics Observed after the Surgical Treatment of Patent Ductus Arteriosus in Dogs

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Shimada K., Hamabe L., Hirose M., Momoko Watanabe M. W., Yokoi A., Aki Takeuchi A. T., ...More

VETERINARY SCIENCES, vol.9, no.682, pp.1-8, 2022 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 9 Issue: 682
  • Publication Date: 2022
  • Doi Number: 10.3390/vetsci9120682
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.1-8
  • Bursa Uludag University Affiliated: Yes


Abstract: Chymase is a protease stored in mast cell granules that produces angiotensin II (ANG

II) from angiotensin I (ANG I) and is associated with tissue injury, inflammation, and remodeling,

especially involving the cardiovascular system. As cardiovascular events occur, chymase is activated

by degranulation to the extracellular matrix. Although chymase has been suggested to be associated

with cardiovascular disease progression, there are not enough reports in veterinary medicine. Patent

ductus arteriosus (PDA) is a common congenital cardiac disease in veterinary medicine. Almost

all cases of PDA can be treated surgically to prevent the development of congestive heart disease

and/or pulmonary hypertension. The aims of the present study were to measure chymase activity

before and after PDA occlusions, and to investigate the relationships between the congestive and

hemodynamic states of PDA and chymase activity. In the present study, 17 puppies diagnosed with

PDA were included and all puppies completely recovered to the level of healthy dogs. Chymase

activity significantly decreased at 2 months after the operation, along with the echocardiography

parameters of congestion. Therefore, plasma chymase activity may be useful as a novel predictor for

understanding the hemodynamics of PDA in veterinary medicine.

Keywords: chymase; echocardiography; patent ductus arteriosus