Resequencing of the CETP gene in American whites and African blacks: Association of rare and common variants with HDL-cholesterol levels


PİRİM D., Wang X., Niemsiri V., Radwan Z. H. , Bunker C. H. , Hokanson J. E. , ...More

METABOLISM-CLINICAL AND EXPERIMENTAL, vol.65, no.1, pp.36-47, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1016/j.metabol.2015.09.020
  • Journal Name: METABOLISM-CLINICAL AND EXPERIMENTAL
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.36-47
  • Keywords: CETP, HDL-C, Genetic association, Rare variants, Sequencing, ESTER TRANSFER PROTEIN, DENSITY-LIPOPROTEIN CHOLESTEROL, CORONARY-ARTERY-DISEASE, GENOME-WIDE ASSOCIATION, LIPID-LEVELS, HEART-DISEASE, TAQIB POLYMORPHISM, PLASMA-LEVELS, POPULATION, SERUM

Abstract

Backgrobnd. Cholesteryl ester transfer protein (CETP) plays a crucial role in lipid metabolism. Associations of common CETP variants with variation in plasma lipid levels, and/or CETP mass/activity have been extensively studied and well-documented; however, the effects of uncommon/rare CETP variants on plasma lipid profile remain undefined. Hence, resequencing of the gene in extreme phenotypes and follow-up rare-variant association analyses are essential to fill this gap.