Resequencing of the CETP gene in American whites and African blacks: Association of rare and common variants with HDL-cholesterol levels

PİRİM, DİLEK; Wang, Xingbin; Niemsiri, Vipavee; Radwan, Zaheda; Bunker, Clareann; Hokanson, John; Hamman, Richard; Barmada, M.; Demirci, F.; Kamboh, M.

doi:10.1016/j.metabol.2015.09.020

Resequencing of the CETP gene in American whites and African blacks: Association of rare and common variants with HDL-cholesterol levels

Copy For Citation

PİRİM D., Wang X., Niemsiri V., Radwan Z. H., Bunker C. H., Hokanson J. E., ...More

METABOLISM-CLINICAL AND EXPERIMENTAL, vol.65, no.1, pp.36-47, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 65 Issue: 1
Publication Date: 2016
Doi Number: 10.1016/j.metabol.2015.09.020
Journal Name: METABOLISM-CLINICAL AND EXPERIMENTAL
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.36-47
Keywords: CETP, HDL-C, Genetic association, Rare variants, Sequencing, ESTER TRANSFER PROTEIN, DENSITY-LIPOPROTEIN CHOLESTEROL, CORONARY-ARTERY-DISEASE, GENOME-WIDE ASSOCIATION, LIPID-LEVELS, HEART-DISEASE, TAQIB POLYMORPHISM, PLASMA-LEVELS, POPULATION, SERUM
Bursa Uludag University Affiliated: No

Abstract

Backgrobnd. Cholesteryl ester transfer protein (CETP) plays a crucial role in lipid metabolism. Associations of common CETP variants with variation in plasma lipid levels, and/or CETP mass/activity have been extensively studied and well-documented; however, the effects of uncommon/rare CETP variants on plasma lipid profile remain undefined. Hence, resequencing of the gene in extreme phenotypes and follow-up rare-variant association analyses are essential to fill this gap.