Resequencing of the CETP gene in American whites and African blacks: Association of rare and common variants with HDL-cholesterol levels

PİRİM D., Wang X., Niemsiri V., Radwan Z. H., Bunker C. H., Hokanson J. E., ...Daha Fazla

METABOLISM-CLINICAL AND EXPERIMENTAL, cilt.65, sa.1, ss.36-47, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.metabol.2015.09.020
  • Dergi Adı: METABOLISM-CLINICAL AND EXPERIMENTAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.36-47
  • Anahtar Kelimeler: CETP, HDL-C, Genetic association, Rare variants, Sequencing, ESTER TRANSFER PROTEIN, DENSITY-LIPOPROTEIN CHOLESTEROL, CORONARY-ARTERY-DISEASE, GENOME-WIDE ASSOCIATION, LIPID-LEVELS, HEART-DISEASE, TAQIB POLYMORPHISM, PLASMA-LEVELS, POPULATION, SERUM
  • Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

Backgrobnd. Cholesteryl ester transfer protein (CETP) plays a crucial role in lipid metabolism. Associations of common CETP variants with variation in plasma lipid levels, and/or CETP mass/activity have been extensively studied and well-documented; however, the effects of uncommon/rare CETP variants on plasma lipid profile remain undefined. Hence, resequencing of the gene in extreme phenotypes and follow-up rare-variant association analyses are essential to fill this gap.