Experimental results for a conventional cyclone and a modified cyclone with an adjustable vortex stopper are presented. The modified design is based on the idea of decreasing the surface friction by leaving a separation space between the cylindrical part and the vortex stopper. The measured pressure losses were compared for various exit pipe diameters, cylinder heights, cone bottom diameters, and inlet velocities for the conventional as well as for the modified design. The comparative studies indicate a similar behavior of the pressure loss coefficient for both cyclones. Additionally, the exit pipe diameter has a more significant effect on both cyclones compared to the other parameters. Increasing the length of the cyclone reduced the pressure losses for all cases examined.