Investigation of Early Diagnostic Value of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase Blood Levels in Minor Head Trauma in Turkey

Polat Z. M., Yucel M., ÇIKRIKLAR H. İ., Altindis M., Yurumez Y.

Clinical Laboratory, vol.68, no.8, pp.1643-1649, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 8
  • Publication Date: 2022
  • Doi Number: 10.7754/clin.lab.2021.211042
  • Journal Name: Clinical Laboratory
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.1643-1649
  • Keywords: emergency, GFAP, head trauma, tomography, UCH-L1
  • Bursa Uludag University Affiliated: Yes


© 2022 Verlag Klinisches Labor GmbH. All rights reserved.Background: The aim was to investigate the early diagnostic value of serum glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1) levels in adults with minor head trauma (MHT) and whether it could be an alternative diagnostic method to computed tomography (CT). This is the first study with the combina-tion of GFAP and UCH-L1 in the first 3 hours of MHT. Methods: The study comprised 88 patients, 60 patients and 28 controls, who were evaluated as having MHT, were admitted to the emergency department of our hospital within the first 3 hours of the trauma and met the inclusion criteria. CT was performed on all patients. Serum GFAP and UCH-L1 levels were measured within the first 3 hours of the trauma. Results: The median serum GFAP level was 1.07 ng/mL in the group with pathology on CT and 0.42 ng/mL in the group with no pathology on CT. The median serum UCH-L1 level was 0.40 ng/mL in the group with pathology on CT and 0.39 ng/mL in the group with no pathology on CT. A statistically significant difference was found between the serum GFAP levels of the CT (+) group and the CT (-) group (p = 0.021). GFAP levels were compared accord-ing to the CT (+) and CT (-) groups with a cutoff value of ≥ 1.56 ng/mL for GFAP, which had 50% sensitivity and 97.5% specificity. This was statistically significant (p = 0.008). It was found that the UCH-L1 level of the control group was lower than the UCH-L1 levels of the CT (+) and CT (-) groups, and this difference was found to be sta-tistically significant (p = 0.003 and p = 0.018, respectively). Conclusions: GFAP was found to be more specific than UCH-L1 in demonstrating the presence of intracranial pa-thology in patients with head trauma who were admitted to the emergency department in the first 3 hours after trauma.