Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators

Bridoux, Alexandre; Cui, Huadong; Dyskin, Evgeny; Schmitzer, Andreea-Ruxandra; Yalcin, MURAT; Mousa, Shaker

doi:10.1016/j.bmcl.2010.04.011

Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators

Atıf İçin Kopyala

Bridoux A., Cui H., Dyskin E., Schmitzer A., Yalcin M., Mousa S. A.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.20, sa.11, ss.3394-3398, 2010 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20 Sayı: 11
Basım Tarihi: 2010
Doi Numarası: 10.1016/j.bmcl.2010.04.011
Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.3394-3398
Anahtar Kelimeler: Thyroxine, Esterification, Silylation, UV-vis, Angiogenesis, Nanopharmaceutical technology, EXTRACELLULAR SEGMENT, CRYSTAL-STRUCTURE, THYROID-HORMONE, FORCE-FIELD, PROTEINS
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor. (C) 2010 Elsevier Ltd. All rights reserved.