Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators

Bridoux A., Cui H., Dyskin E., Schmitzer A., Yalcin M., Mousa S. A.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.20, no.11, pp.3394-3398, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 11
  • Publication Date: 2010
  • Doi Number: 10.1016/j.bmcl.2010.04.011
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3394-3398
  • Keywords: Thyroxine, Esterification, Silylation, UV-vis, Angiogenesis, Nanopharmaceutical technology, EXTRACELLULAR SEGMENT, CRYSTAL-STRUCTURE, THYROID-HORMONE, FORCE-FIELD, PROTEINS
  • Bursa Uludag University Affiliated: Yes


Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor. (C) 2010 Elsevier Ltd. All rights reserved.