Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators


Bridoux A., Cui H., Dyskin E., Schmitzer A., Yalcin M., Mousa S. A.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.20, no.11, pp.3394-3398, 2010 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 11
  • Publication Date: 2010
  • Doi Number: 10.1016/j.bmcl.2010.04.011
  • Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.3394-3398

Abstract

Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor. (C) 2010 Elsevier Ltd. All rights reserved.