Akademik Veri Yönetim Sistemi
Agri, cilt.13, sa.1, ss.13-18, 2001 (Scopus)
In this study, postoperative pain treatment in 60 ASA I-II patients aged between 25-60 who underwent abdominal surgery was assessed regarding analgesic efficacy and side effects with PCA. The patients in this randomized double bilind study were divided into three groups and no premedication was given. Thiopental 5-6 mg/kg, fentanyl 1 μg/kg and vecuronium 0.1 mg/kg were administered for induction and anesthesia was maintained by the mixture of O2 % 50, N2O % 50, and isoflurane. The solutions given to the patients were: Grup A: 100 ml isotonic NaCl solution with morphine hidrochloride 100 mg (1 mg/1ml) Grup B: 100 ml isotonic NaCl solution with meperidine 1000 mg (10 mg/ml) Grup C: 100 ml isotonic NaCl solution with metamizol 10.000 mg (100 mg/ml) All patients received 0.05 ml/kg from the prepared solution when their pain score were 2 or greater in the recovery room. The PCA pump was programmed as a bolus dose of 1 ml and lockout time of 10 min. The patients were assessed every hour for the first four hours, then every 2 hours for the next 4-24 hours and every 4 hours for the 24-48 hours of the postoperative period. Blood pressure, heart rate, respiratory rate, side effects, sedation scores, the number of request, the amount of the delivered solution and verbal rating scale (VRS) score were recorded. The comparison of the data were statistically evaluated with Turkey-Kramer and Pearson Correlation Analise methods. Analgesia was significantly better in the morphine and meperidine groups (p<0.05). The consumption of the drug (p<0.05) and the number of request (p<0.05) were higher but the frequency of side effects was lower in the metamizol group. No correlation was found between the number of request and the consumption of the drug. In the morphine and meperidine groups, the side effects were clinically well tolerated and respiratory depression was not seen. In conclusion we observed that the level of analgesia was better with the opioids and the incidence of side effects was low with the non-opioid. More investigations shoud be done in order to compare the effects of the opioids and non-opioids.