Citicoline and postconditioning provides neuroprotection in a rat model of ischemic spinal cord injury


Turkkan A., ALKAN T., GÖREN B., KOCAELİ H., Akar E., Korfali E.

ACTA NEUROCHIRURGICA, vol.152, no.6, pp.1033-1042, 2010 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 152 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.1007/s00701-010-0598-5
  • Journal Name: ACTA NEUROCHIRURGICA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1033-1042
  • Keywords: Apoptosis, Citicoline, Postconditioning, Spinal cord ischemia, CEREBROSPINAL-FLUID DRAINAGE, CDP-CHOLINE, REPERFUSION INJURY, CEREBRAL-ISCHEMIA, THORACOABDOMINAL AORTA, FOCAL ISCHEMIA, CIRCULATORY ARREST, CASPASE ACTIVATION, ANEURYSM REPAIR, BRAIN-DAMAGE

Abstract

Ischemic spinal cord injury is a chain of events caused by the reduction and/or cessation of spinal cord blood flow, which results in neuronal degeneration and loss. Ischemic postconditioning is defined as a series of intermittent interruptions of blood flow in the early phase of reperfusion and has been shown to reduce the infarct size in cerebral ischemia. Our study aimed to characterize the relationship between the neuronal injury-decreasing effects of citicoline and ischemic postconditioning, which were proven to be effective against the apoptotic process.