Citicoline and postconditioning provides neuroprotection in a rat model of ischemic spinal cord injury

Turkkan A., ALKAN T., GÖREN B., KOCAELİ H., Akar E., Korfali E.

ACTA NEUROCHIRURGICA, cilt.152, sa.6, ss.1033-1042, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 152 Sayı: 6
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s00701-010-0598-5
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1033-1042
  • Anahtar Kelimeler: Apoptosis, Citicoline, Postconditioning, Spinal cord ischemia, CEREBROSPINAL-FLUID DRAINAGE, CDP-CHOLINE, REPERFUSION INJURY, CEREBRAL-ISCHEMIA, THORACOABDOMINAL AORTA, FOCAL ISCHEMIA, CIRCULATORY ARREST, CASPASE ACTIVATION, ANEURYSM REPAIR, BRAIN-DAMAGE
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Ischemic spinal cord injury is a chain of events caused by the reduction and/or cessation of spinal cord blood flow, which results in neuronal degeneration and loss. Ischemic postconditioning is defined as a series of intermittent interruptions of blood flow in the early phase of reperfusion and has been shown to reduce the infarct size in cerebral ischemia. Our study aimed to characterize the relationship between the neuronal injury-decreasing effects of citicoline and ischemic postconditioning, which were proven to be effective against the apoptotic process.